	   SnapGene      1GCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCGCCACCATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTGGAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCTGTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCTTTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGATGAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAATGCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGGACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTATCTGGCCACCTGGAGACGGTGATTTTGGGCCTATTGAAGACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCCATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAGATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATTAACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAGAAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAGCTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGATGGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCTCGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACTGATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGCGTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGTTACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAGGTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTTCAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGGCTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAGGTCCTGATCAGAATCATGGTCTCCCGCAGTGAAGTGGACATGTTGAAAATTAGGTCTGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAAGGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACCATCATCACCATCACCACTAGTAACTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  8c                  $   !                  !      *                  #   "                  #               !                                                             #             +      %   -            %                                           #   !      "         !   &   4                     
                                                     (   !                           
                              "      $         !   &                     !   #      
                                                #                           *   !            $                           $                                                   	               %   *            (   #                     %               &   &                             !         "      "         
   ,   %             #               #      &         ñ yìlmnsx‡ˆ©×àá…	†	¯WWÙ÷dæ—Óå yzœ¸úNìí‰’ªV
ø6;O¼Ú7eçä¼Œ+–c – ò �Ëê±otâ	“	Å	²
]­Xø˜=«æ · `æÍæm¿y´Ø‡	Ø	x°KXô¨z,�ìÔk C “�ûOÈ¾?rý4�’Š
ÏÛùaçf�$ •”H]t•B“É)
¡
¸
 7íƒ¯á8ò�å¨è,ÅLdt! f{:pÀí�«W
 &A]éS–ÈÛèÊ£w½Ø—ä¾ z¹Šx„î~
è<¶ÂP½ �D÷’Ì5ÄŽ�\pu±		Æ	³
û
^Ô€®ùn½ÓqM> $žåês²Uã¸Í]wœ²ù&G„ — Lm¢†ª	”	Ì	ì	o
M¸Y¤WnÕM™Î¬ç F ó þë@û0@
ô££™Ä ýÛ! œ açînÆú	±L›>Nf³êí˜k{±Ê0q�íº©u‹Õl o ®õR©«çGz¡©	Ð
yîY�5?iP* t 40\ÄÓµ½Ùl	ˆ	Ä
‡Òäfn‰¢öÿA�ž±7©Îõ©Ä«>-á‘Æ‰ ¸ +ì¶ÎÀÙ	g
¤ªÞUŠ¥Y$Ö�íø D üÉ>¾„½@‹Ä¢¨ÍÐÜ$dìQil°=Ž Pj…¿%sŽô=“b|ƒgÊ¶fô M ”žSþ\¶W
AèlÆ!4¬P| X yò@¹05z
ºúÙÝäK’Ü´ÿO¬ñAº# ˆ ‡¦Öu¶ã”Ô
Å18OîáâžæÎë
€ùéø-îMž" 8± I^Gu€–(?yCÊ¹
~Ì„^ ¸9óto­ÆØuÕû ‹ –5”
¢
Üwð°Tàhe}Ê  •5Ö¤¹Î*
8à*÷9î©®  ° G;ŸÁå•¬É	!>’‘êiÉ<  ½ gqQöå	Øé‰Ë~‡®˜¿ Ï |ÇÐÛŽš	À	M
X
a

4B—…‹¤d¾ÌÍ# €Ï'mî ÏÒ'^¬ýTÌÜ0xƒ‹ÙåN£µãåö# Q]†Ùâ“ÝÁé÷ïé	û	é	%K>o¾L_ž	 } É lÙy…l e—‚Ã{|%o Ö {rºCi‘ÛqÜ
‹t=ŸQ•€�nI y 8CR.U‹ß,�˜#	±	ÇËÁ_·ùcg†ºK¸x! ‘dø�“8��qv²		Ö	
Ÿ
¶
þ
_ý�£±UoëÑÔ¦ûo EÍÅ� !	Ç	Ë]Ö¶ý;GN? < > »ñŽ6‹]	¦
¨
´
ü
›¯´ì1yrÿm R ¹â9°à
  	ÕRúC©3¾¤Â¹  O ë³YõÓ	È·'H{: å %mŸæÊ¯›îÎ^x�6ñ8 + `–½-åKÅ×ä×
 ‚l|u¹³óú…oÎ 	 ³ ²Ë#VótcVCR…ãR @ Æ £q%êøþ	(Ë¥R*#g%WZ¿çõ~ñz " ˜ Û ^‡	p
®
¾Ö·)E®Ï­ Ÿ Mn ¤cÅûí	+µÿX­o3“NVüL€7  û d««e	•	Í	


pN�¹/CZê§µBÈ\=šÌüè G ÇúZƒ4@¤v} ô T‰Ü3–ðAJ©Ê_v	ª
ð
8¦Â+f¤hÅtê,^Ž …ÿ¤ìU1¸SA
õxgš!S³ ‰üL.
½
EÐ\ÒnþÜ Jkè2¯Çø			ô4™œ´ëM×bl¯¶Ë»KÌs¼ V ® òo’
MÊÛOgîm²r®L´ªvÖm � Ä bïa7	É™s(1‘éŒ5 T ¤ }îû		4	<	ª²ò!?A%Õ`|�«îR jóP¡í# ¯ S	]E»{ž	Í
Ñ
ŸJ¬åïZ"ï�“©^alõü« Z p à»`˜¬èHaƒÛ
ô
#<ë”6Z©ÖRÄCQ[   „ öä›%y²IN¢ýà
ä
(,0¢ÔC'%<JåLQj"¡   ªe¡ª	Fzß5@ï+ J ¦ 5Y	BœúÌÔ‚Ï¦Ô|
ˆŠ£ BŽŸªÞöÅäªIš¬-).OD¦î e 9]ô'	¼go÷E²»ÏŽ	Àâ0c% 8 u ‘ © )1oÄìûœ¾K	m	¢	ÓåüY¨pŽæýª	”,†Ãð2’Š?-  1 {¿à/Åè¶ÚB	{	‰	Å
ò�!s8Å!~ŽŸ¿?b¡­û"*¡¿Çy”Ó�»  i	^
¥«V•˜Tyñ't‹¦”ÁÞ%Àåî(ùX ' ¹ rÆœ&·íñ"0	`	Ú	#3{EZ‰–áA]1£ 0ñöw}­Ï×âh
®´ßl,6—óüÖT×j% ,<J¦ÏíýÕ¦;d¿Áÿð6	>	à	ô	JV_ku€´×¹Grñ(DGž‡ • xMÊ°åël¾†ß’	Ä	U
±
®:å»�ëbjªä  o‰“>G\w¿~ŒA}ŒÎ%ç\RÁñ~¢v×ãK E ý4?T…ú/[ú
L£m± n s › í ÅÃ
Ï
£©ÑÝãeí6=jÉ#=�¹>h¨O i„R¸½[ƒ<¼¡cã‘hk«Å 3 Š †4tµF¸>xÍÓ
Ä}ßöêín÷íg­Ô ¼ &äõ”=„ˆc‚Ëä}Ì;õ Q-kÀØh�d–è	�Æ{· Q º�áÿ¯Ÿ	Õ	
ÊQëÐ¥:£úþl¸ÿ  * N ä l•±Ê"UäJB®XÖ
Ç�ò59ðQ ! Ú ú Ÿ]é­
oBéQÇ"û(f<DK­ô}û 2„ˆ¨TK·
¼
ï
7D3gm] j`16|÷		3	;	©ñ3ÉÚÈ$LlÔµè­JKòË4»# Y _ º$x`‚�Ì
ß
ó
';Þ$;ä P’¨]`Õª!B ! d Xnz¾ÃóúA›Óz	{
»ñûå�“©H¾ ú()/“Ò & õ%¬c¾Öðð&ÝòF•àä" m r 3ˆ’[v¯
‹äêùk…T
9<¢È"uºÖê§âNai ‰ ,×g·ãZ‚;c•Ì<Åâõ‡zì~�: ¹Éƒà§IAJ»
Õ
ÆP€êfÏúù8ïó\·þ! % c Wm½ôùšw½{	y	Þ
&ð2Èïk:ãñŸç'\.ÊŸ& ó2‘ø®	Hv�Š@zËº
Ý
%ï¡9éðÇô!†tÕÉ¶`ý4 \ ¯Â��÷—);·	¸	¹	s
t
u
‡
ˆ
íî… XYpqrs®ÓÔóôÆÇÈµÇÙEFS]^_Ö×ü ] 'è°Ãâ9²J_˜*<D€	v
‰
†_,5¹ZîõTvØà ¡g!Éº	$
Í`:u8<¯ÛÈÚGÜ (ZŒßé]™Äãb`™=w
£
Ý–‡ñ`i Qö/«UwË á Wu>8š
x!6ÐØHi‘›f~•Ùá ^ € ë :—K+6EŠ
•
™
ë
3�-ºËï!   Œ ç ±³�	…±�Uá[6
 @oµ�
]ìªT É j Ì"MOº+
.
„
9~ÎÕøŸï9HÝ ¢Ïhÿ–×±»	%
Peá+úa`Û°�¯Û !Y6:¥ÊÏ5
ö
>v;v:r=ÜX 
)�êB^šäè Â»Ê	…?‹ëd~ˆò¡‡+  † [à<çÔõ*jÙá–>x
"2rÞažÊRÈ÷¬³¸ ± bÅ¢ao#¤
jvûµ½xÌ  ÄûHcæš¤­Ù
â
!*�“’—Ejâ0/=qV  â ÿ jvhKR›æ	
BÆ"§;ødIj¨â X÷9R
7çê„Ù™gÚ ¾ ÂærZyÙ–Ä À ?ú¤~ØÑŠÌˆ¯’œ…À  � Ì Ó NƒÖ�ÚGtÓ"ÍÜFP�l
5CHÛ»w"`Â›° Ð Þ ì ÷ ø/<;L|Ñ,WÿÁ	–
ì
4N¥eÍð˜ _ ˜}PÈMÇ›	N
Y
b
€
‹
�™†.>õ¿WÎ£ÆÐó ˜´7bgE
š
y¿j½˜ŒLÌ�!a 65ÐK‚	Ý	(†úÑÖœ)3²V\d†lä( è ¶¿Z²Ð)�(!'{œŸ¥Óˆþ{¾~'fsž»âSÐ7Ò¤¿§!  - � '²+nŠïô;
æ
._iUÝn
üyŒÚFO™æ$ �´\æZ„­ÍÁÙY1„æ`¶4÷$ µ ï "œãw¶õÂE§	ê	
LÓß•Š”r AA¯ê?�ÚM7«…¡ R^‡Ú+”c	Ñ	ü	
&áµUÊ
 Â pÍÞêøðì	�
H¦p¿^í`ÿhŸ½w #gmPa€Ý| Ãð&fI  h k ~ ÍYeX»˜,
…
:|ƒ*3ÉÓV:Þ Ê ´%XNzˆm!ÏÄÖù±¦Âñ
 ØÚ†f*	/
Ñ}åp £&-¨£jØÝ+&
uâ.>, G%’Œ™)J × H…üThr«Œ�aÜç‚ |ª»i —’,	¼	û‚°+  sÐDÓÜ²%
1
QfåRb–Ã±oTÜ
�‡ z 9vZ-$	È¸úd‘€ÇLA±Ãyžë ?¬Ÿ/DV�Œ7;àu™¢¨Ð÷
?ÂÅhŒ>,–ÝY1 	ºÜ@‘¦‡¬	Ìnµw‡<ÎàB D‹"SÚË²	6
`Òõw»;s¹ Ž_›åùéÌkrw‘¨³Ö×	\wJ¬óV§öy+<" B ’e”Ç9½qüs”‘ 

(
 
·
ÿ
Ú@`ì
‚•Çæœ§Ä Cr‘�¡©Ž		Ë	n
V¢›Òø%FÃüpƒL,$ *3­ëôQ¨/[µªÃ¼†þ@Œe‰¤²Íé—/pìŽÕœˆ÷ L 
=ñ$?VÃy
¹Ì#JþkÉ<Oeó@¹ ‡ ¥ÕÕ£â'47Ûß0àŸ·SÍ	ø|�É!  Î FÎÆlžÏÚPÎ Ñ¿	È	ä	L
~
3‘�«×Ë/Š­´& x È Õ 7P\…Øáq’ÜTè�Þö+kÚ—"	ú	Šs^ø=b”K�$mH ; = �¸7ŠŒß	ž
¥
§
µ
ý
¢°T³µü02ÁF ² ¼òbÄÖQ„ôÿk{í¶znÍ ? c£ªp$÷ú
œ.þ¬½´U$Y¾ ðy Æ£ïIÉ-R^©
¥ÁÏ*eù[w?ÑRsé+² S £ I®˜rœ®ªQÿOr ƒ ºãdšD±HÚ
ã
"+žêEä“¡IK4Y¨Ã!  0 7 � ¨ (ß.ç›Ë�¥¡	Œ DroÝã,¿1¥b>€º#  ¥Åüv¥:áìþ!/	]
³”ÖSx¸Fkszû'D¿i'\0†W ” š wìLS.ZÞ‘	Ã	°
â<¸ã
 ´»ç	�éã|2Ó   P Ù ã ù k1‡­èž	Ô	
î
6CÉPe;Jk  i_œö:	Ç#Œ¨ù§(IÑ© $ b løj	S
y¹7ò9h & çfö‰È:	r
8èï…íò 
Ú´Û à æ Y=7
˜
ŽœÿPÏ5 Gš nËþN°ƒ
Ž
Odë_žÚ€ 	aÃúçæÓôiØºØ
 œq�´†p* ¿ JùYQ
}ƒ Ò Ý —Õ.;sÒ~LÆVfD
k
˜¾iGÚvôV—š¯ÅÏ , ¾4±[å:
ùƒz½2mrÀºØ	Xc…ûÏEÑ
¦ ´ Á î !›Ì*ô@D	¦	¥ÙÒÞg”„‰“ 
 g ³$W×XdW`)	Âäe°Á ,§ûSä(S*€† >u€t†´Ñ‹ÆÍ+•°�ê A ¬P§qÆËr�ÿ	m
Ù[IÌè¦–x÷$Â‚öÃ# w Ç Í Ô O„×p‘ÛSÔ#ÎÝO&¾	ù	K
6ª<jÌ.‰ò{œÈ : ¢HùQ
þÀ)øýSZ¼T#XÀè± ‚ ¢ u™¤ÊëýG.	\
éDqrÜq+Xh&N[a… “ ™ ø 0-�	�	Â	¯
í
5¦ÐÒ # a ß <ekMˆÇ 	
q
‚
�
—
O¸ìñÿ4F³ Ñ Ü ù3°}ÒhXP
—›q¿×W„ÎÐ	™¥® í  š=+_	¥	
Åf*”¯'é) ¡ Oo¡¦RÊNÉüø	J
[
Øè¿YpöSWˆÁM�Ç ` ™dÆ�	œ	¤	
O
�
Œ
–š	 ëþÏ²(¤Ñ*   N¥QÉÈî	ï	I
Z
‘’“”•ÕÖ×ç	½¾�¶?@AB45OPQR�ÀêýA'��! ~~½€ž2G	M	Z	o	ð	c

,‘‡·/C®.6”Ùò�XB-8‘ô « ™z�H	f	ñ	d
-k¾0[ˆ¬î¨áY>ØÐý ü ¬¬µ8Î	™0DCÝ]Œ�.’ îåchÀN	[	
F
›
zOº’/9DGšëMÚóÉ‘"CbÍ9$ e¾ý”Ÿ3Q	V	p	–	 
qÀžÿ�¸¯Í/‚ˆ7•¶›‹éõ }‚êÑƒ	>
e
l‡ç­5W¡©âÙÑ 6´Ú¯	#¿×û�\‰„]þ È)ûX[³A¥§eZwm{~å H ¬ 7š{LI	^	g	Þ	ò	.Ò1 *4ïŒ˜ ‡?  Ážªâ"|­¶Ô«
ñ
9§ÿ¿¼ãiD£8IÓ‘ë¨ é UŠ·Ý[—³ñ*K9w	3
é
1Ã:gÅd|Ñ¥V�à“ õ ý À4 )Ë(	�`g‰|šàdtŸ¥öÆ^�	-_½Àƒ¶ uF­ÑB ¦Ï	,l(1EÇ#�ÁTý³ÞÁu/$   . Ž í³ï,o‹Ç2õTiÁœ
±·�“HTyý›"PšDc: ( ¥ÕVò¹æd¸Ü}	B
0›NŠ’T O	

G
»ö:Eìo€hÊ,�Û%ƒÎç%‰  †ð\	<
ç
/{P`jVÞ¯ÛôzG#Þ´ Ò•—	Shr}RŸÑ®¹ÂƒA·ÓZ2–à5ê €€ˆ¿‚Šþ1CÞ]
!
Á…ŽÑ]Î0Ú8$oaÉø µ ý/4D	W	bu Î°‰±…çÿÕÝŒ 3 fM'çR	q	‹	¾
Ç
F[ô–£Ýqœ·ö% ¶ ð x·ë
	„	÷5VN»Ø6cã–‹*•Ò ~ƒ3Èèµ®àÉçs½ #�äKléöÃ°ë	?
·Óóm¢·ÌÔ\v¼L˜ÍÚ ÒFù	k	¨	f
Tmˆ¡õš�°M¨ìÃXª°à4ÅtŠ W x/óµ§ë{ØÜP@‚Û³N¯µð«{ 7°“
NË)vï]s8¬×ú ¯ ™	`
ühŠM†¢âÿ" | BBpÛ°	Ê$ÀJžfn…^z¹J€wn cð8	 	šü\ÕB¨êxn	 _,ÉÒ	âšt7 ž Å bÄd	ý		
*'Ê´¦)2’A¶[VæË6 SˆÛ•u	Y‚fu|� U ­ Ã ñí		‘
ó @Ö_a'i³ ì  ß\—Mü	/I«ÓB!&îkôQûZî% I ¥ 8ëù~Î&	A	J	X§�ºüÄ +}…�™ža¬Âï !NC ¾xí* /;IqÎðÔ›|ï5	=	_	h	ß	ó	IU^jt­—³"2+5q“–ÀðCÕSˆ@¢ n=F}|ŸÂ
Î
ù

K­æ[ 5Àäð}Ž¡gJ© » 
hƒ3Q¼E·wÒ
 Ã€ÞjªÄbmËöì¬  ) ° !TŒã®¬
n2ñ¤'9¢Cýú( Â$^Ÿ«#b_Õï�Ò	2	Ë
ò
:¨ð%#ÓG½
E‘”_JÔßã’ 3# l q ¸È‚V¼ß+Zf™âY¼é:Ib„x	;ÄÇ;je&[}¦[á [ ®Ááò1Ž­¶	#
†
Ü
$ì+4_ÆW7;ÒÅDR\ß   ê Vt‹Þ\˜a™ê
2„• hÊ.ª×�” i ?´ÎLX9-
4
õ
=}uùÔ\qSŸW … A¡ )nà
"£á
)„1ŠDc}áu úÇ²¼
.·  þ iÁåA£Å¦×æ:÷c§„Ã Ë ö M‚÷�ÙFO!{Ì³Oaþx¼=KM_Ž`Á¢ò% µ&5Y(œ*‰&z›ž¤óJÜ	å
-Yh‡ÐÕ›(}&eR_˜k3¾# v®ëb	Ð	
Gà€þ6~´¼vq f‡{)2ÈÐÒÜU¥ð  ©%G„Ò¢gª$*+	0
-F$‘Â‹˜æ	 Š«žÙC¹Û?¡§«	mÄ�ô@ßAÂ0& 2ó.Z´¼
pŒ©û“¨j§Õ'
v?	”«UÆåõ.›*�šE›K;&  K 6	¤ðk�Ù¢Íÿ3ÐUÂã	}
‰¸�Ú/�ß÷I“Jœ#ld  ©·îÈÃÕPƒ‰Þö,ó�
¤Îd-¡z«²>³Ð/Q*Eï   / 6 � § ¤'Þ-C€²‹ãCw ·nyH&J›­¾Pþ§ Ø ^†¬ºçÝ9	áO‹�èâ1 ýõi6~	Nc�þ
Ù	 Ô:IøÑóUe¹9
C
j
½hpøF¼1œ‚bDU) f )¦ÖWs(	³ÐÁÝã“ƒd 9 v «pÅ˜-	½	
ýZp©÷qç;ü•iË-„ ’ *2j¯g
pÄVƒ3“&è! }¼�1F	L	Y	n	Ž	£	÷	
H
Ôæ¼�-Øñ‡Žé@±&,Ž ª yíü“ä¿P	U	þ.8F™«í�‡àÜ‹×ÏŠ |é³Ù]	®	=
"æW‹— ¦z"  tEÀá2
è
0k9ßcÆ"�ÀÄcõü{¢²HÀU¼ß‚µ   ÔÆñ·Û|	
°¶ŽS‰®+$‚Ýˆ" 2 ‡Ñ0BÝ&C	Š	Æ
Rg|óQatÐ@¢°Ü#pÈ•Ôß j	öS ¶ÒU¯ò§ºÂßÈ[u3Äæ)—‰ { w.˜	_
¦Éz(Iuey¸Iïázù!
 Ãt	™Ô�@t6,  .:HïÓ[–Í%	@	HT]is~¬W–Œ¹û’•Ã*„&BÁÔMB²úŸìYë% ( º ÿ‹‚2<D^vîÑ1	Á
Ê
ø
	mÂ$4Ò1F	�¡ÊÞâBù2 >sÇ�­ÀUÞ0W�8áµ	"
Æitø^[%p-žZ  Lh�@ŽØ 'Eÿßš£òÛ	@Xwƒ†»b|9b—^»2 ¨‰$ƒ�¸>©#)êa	
Ã�óÏÛŠ—?»¤# 5 1ò¶»Ý¨’¡§ÂþOˆòâ	ÍÙcv¶mx±ô=Iš²½Ïk  Ó÷~Ð58	8
i
MbàýØáC( 
x®fã0E	T	X	�	ö	o-7˜×ßU†èÖ� AØ­	¯µÏˆŠ¥Þ -GîÂÌ?	s	G\õµHÓ)x?Htsˆø # =Kg§þ�×#TÝ=(é´	À
É
Wlv‚ºasò÷ º�º 4 Ò§eÁNñ7	S	Œ	á	õ	7
LaØH™¤¼Þ'& EFÐÑŒÖÛÜ<À èr	³	¿
È
K`�öEFG—˜<=>rŸ¸¹÷&  -   qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                      %                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             	                                                                                                                                                                                                                                      $                                                                                    #                                                                                 	                              
                  (         
      
                              
         	               
         	                                       ,         !         #            t   V                     U                                                                                                                                                                 %                                                                                                                                                                                                                                                                                                           	                                                                                    $                              #                             	          
      (   
  
          
   	     
   	             ,   !   #    t V       U   oF  pP  pj  p   tª  y  ~¶û	Ç_Ð	»ÿ¨¡ñ7
~™¹Ò[	ÁØnÑ

) =”<%”
ÆUw —K ,¦íå¾¨KŽ •! !
fÛ
#¨� ,¦ÆíJb»2¦¾ûý'	B	`	Û
#V¥«£÷™Ÿ8grós¶(aå‹0\½§ïÙ^n¸yôW^|n^n^y^Ack
qÁ
	©
ôÿmýêý,cÅ²Û¿‘ ~¶á@µ¦÷
ú¾»Ì}à€Ù¹úP
ÝQ†Ù“	¤U|ƒOÜµwJsQ©s©	±Ôù?@	Ã0K´ºTÉµT‰¤X÷] –5‰
,¤/ßQ†Ù“±o¾‹	|jÂ m!ù× …«yÝ3¹.3.é³õ¿Þ ;–
Nà[]9¿xÕ3.µy¿´Ø‡	€¦±Ö”¢à
(Cä‚Ê¾Î Ñuþl ICóãÁd|3	;	±{í©s¿ˆ	”	©	Ä
±Ôù>?�Æ™ç¼pûå0BÐÈi9c{ßâPŽ¶*Ð	à@§À
ƒ¦àõUbô™²JÑÇZ–`”©_i	ñ¦ÁÃ?ÍTÉ
	¦Ôª)T¢Jâw¿@ƒb¬ y9¿´Ø‡	xÕÝ3¹.b(Æ¶m!ù|@ƒàbˆ¶áV ,íY]»˜7íž¢0	>	i	Í
à
(F Û#?Clp¦Á(E²-Zá@ƒbm!¢à
(Cù*í]SÛw‚Øääõ® g5JÜ	Ð(ü%F$õdÆëþ²Æ³ÒShr}AÓy¤¼pû/ßå0BÐÈË
‘_€–5â
*ÁåÆ JƒmùÆ Ÿñ¤«JUÍ	

|ƒ3.¬ ­*1oê(C| ý9¹ÁÃÿ[“¿:5âhÊ,|ÆÉ¶ Â ·o@ qþ	i	¦ÁÍÒGMBì¥yî³CãÒGƒj³9ci{ß•ûy ,Çcx>
¡ÙŽ\¬< ±"UbQQ[	n
Í¹í&]SÛwØä€¬Ì0ƒåµö#1ò»<¨’§Á
ø
	4ô�š…³Pj¿Ž¶¦ ]B	ŠïBŸ"Iš¬O�“^¦· +ìŠÍû¿ÀØ	¶�ìýÛõöµUºt)ˆDÌÄŽÆ	M>B ¦lÞÁ/Šû¶ýÛ]	ï"�“^¦ BŠBŸIš¬O¦'š£òÛ	X†|—2ŸÁÉ	>êE§	Lß˜ ¦ ]Bø		«VŠ•ïôB™œŸ‹ë"”Iš¬¯%ÀO�“^¦ùsX1ò»<¨’§Á
ø
	õöµU4ºô�št)ˆ›%yIä
,Ô'%Qj" Gå¬’‘i<-&
u>Œ™J( ÿ‹m1¡Bù:À« éÈY_3 Àá¢HK 	ðUÂ¸Idy¸í;O¼L½
E"œãõ¨ÂÝ+ê	, €Óð&) K ’ À	áðiUÂ¸I¢HdŒ®¤9¢ý%¢*-F$‘‹˜Ýé÷ïo¾_žŒ-GîÌ?	G\)		4M×b‹ rCSÛ¶

—Q‹°T•àln$JYn‚^u| }ï‚¶2TÁ—	·�çH­i·›"àëcxãT	-7˜ßÖ‡uã8éMmÊA�^¯	!	+]^�)t®Gˆ Ö¶”áë€O	Eì€ÛÎ‰S¶
lrCÛ
Q•nA�!	+]tG‹ —‹°Tà ø	«V•ô™œ‹ë”¯%ÀùsX%Œ¢®*-F$‘‹˜¤9¢ý† ÔáÞžR÷ü ™]Œr5U ­ Ã ñí		‘
ó @Ö_a'i³ ì .:HïÓ[–Í%	@	HT]is~¬W–Œ¹û’•Ã*„&BÁÔMB²úŸìYëJkè2¯Çø			ô4™œ´ëM×bl¯¶Ë»KÌs¼	 ³ ²Ë#VótcVCR…ãRd Xnz¾ÃóúA›Óz	{
»ñûå�“©H¾ ú()/“ÒT ¤ }îû		4	<	ª²ò!?A%Õ`|�«îR jóP¡íØ ^†¬ºçÝ9	áO‹�èâ1€Ï'mî ÏÒ'^¬ýTÌÜ0xƒ‹ÙåN£µãåö#¸ +ì¶ÎÀÙ	g
¤ªÞUŠ¥Y$Ö�íøj	öS ¶ÒU¯ò§ºÂßÈ[u3Äæ)—‰… A¡ )nà
"£á
)„1ŠDc}áu úÇ²¼
.·& d t ¸ +4ì0X\nz¾Ãõ%¬¶ÎóúA›Äc¾ÓÀÖðµ½ÓÙl	z	ˆ	Ù	g
{
Ä
‡¤ª»ÒÞäñûUfn‰¢öÿA�ž±ð&7Š¥©Îåõ©Ä�“©ÝòHY«¾$> ú(-F•Öá)‘�Æàäí/‰“Òø … ¿ þ 	aiÁÃúAJ¡åçùæ Óô)inØà
"Y£ºQ
Ø
á
 )A„œ1qŠ£Dc}Å�áu} ¦×æú:ƒ÷´Çc†²¼
.p§„·Ã*R^‡Ú+”c	Ñ	ü	
&áµUÊ
ƒ ºãdšD±HÚ
ã
"+žêEä“¡IK4Y¨Ã/^ € ë :—K+6EŠ
•
™
ë
3�-ºËï! AØ­	¯µÏˆŠ¥ÞD üÉ>¾„½@‹Ä¢¨ÍÐÜ$dìQil°=Ž# a ß <ekMˆÇ 	
q
‚
�
—
O¸ìñÿ4F³E d R^‡Ú	+”ýXnz¾Ã4?ºÜóúA›@T…‘¦ú/‡[Óc	z	¬	Ñ	ü	
{
ú
»ñûLÌ&nµáåw£‡�“©<H¾m Îú(±)µàB/U“ÒÊ
6´Ú¯	#¿×û�\‰„]þ  �      _  4         47»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k�½7H0ó±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ¬<?xml version="1.0"?><Features recycledIDs="12" nextValidID="13"><Feature recentID="11" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5190" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4399-5190" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5191-5259" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="10" name="NeoR/KanR" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2103-2897" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3643-4228" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1265-1693" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1707-2036" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="995-1219" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1887-2022" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3071-3192" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5260-5364" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>ff78c584-a3e1-4c98-ae91-a20e1b04a45a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="1:59:14">2023.6.5</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></BottomStrand></StrandColors>  hý7zXZ  æÖ´F !   t/å£àË'] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_x„%çÖw$•ÖPý…°rÇ&ŠŽ\xv9¼î�±ŠÙ6·9Ù�êl­Ý§roB\µµ3òÝù=oœÄJtÌkŸÂí€ªÝÁœ¨Ón7¬\à=¤‰«NbóY ySfu^¬Ð*Ó±À�©GÖ�d”$C’\¯n2Ñ}ûØ-F¾AU¾K3PlPŠÿèéºyÍ~9³+e;Å?hg£6í:gb*µ�ÖìºFÐ)�AÝ>ù�.<µttq½Û ç±²^®ôZh´ò|G%‚Ëwž0VŽBÞ/ø¥ë^—ÒEóI5Y*˜²BCU¯Ê€ékEÿûSå)4·P…jÏT§îM/Œa¹U"Û¦Bœ.¢ˆ»©ØÅÒí7ž¶J¸~£ÝN�—Æ^QKÉ´kª²Ó�¬¬bÎ…Ÿ{lÐìðø—NA�™�‡%I¤ÚXX°�œÃÅ4ˆù{¬r Ô¿†“`ShDI¤Ã'H™mo’nî/9Ð»�Ã—8‚r¢�Vüm
Ó 	ù�³'a=Äb}ªïrñè6Èø�[?bÍ¦2+i›w��rŒ±Èr³[ÜÔ_Kh�U�å~îyôn$ï~å¶eµeÜÏÅŽžÚ«‡9Ð~EãŽÙ®WjTŒ£T$.öEMvPÈÜe{kµ6Q¿>õ.Þ	x„Ìe Ühº0/ÔÉ€¸¨TUõ¢‹gÊ0c5íiëüôÿmè’?v­ò&o"
$¿¾!-%9Ñ‡€²Ü(³¤”/6ñ÷hw¯Ó�ä7EÕ\iøŒ¶>€ýÒÅÔ·$_Â„5ËwˆìpD•Ã+OUM>EÅ«±Û~5ó=)0Ž·8æpÕ ¤äâK§µÈC<xŸìïÚa9Ê¹Ýô€t¦°}N/8Z5¢ãlnžÿ%¸¨l¡ô[¿œk¹à(ZD_s
©9cT@¤Çq°7Ÿ2­ò[�Ø›{}‚§%�ØdDqý ¡y²\ÉÕ¿çªžZùMíê
[=ýz(£ ð`Ì“àWŒs;Ÿ@ÁÒƒBNkÔd�‚Ñ;ïUŠƒa�sVêóºt„RÁZB�m^Ùy7îß@ØBœa³ÞHC	ˆF¸2Êå.’Øz/æ-%^Ú`
‹¯ãÝ\b9bˆ|?ßqÉ7geÝ�mK£RrKK�KÃ_#®Ì¬éÍªSÄ—8K”—æ
ú‚À�Àà»g•Ùª9\E«RV¾¬ý+ç… ?”lG Û¤}ÉX|wûm“Ù‰ºÎÜ»è› u�4Ÿøw]ZÞA¤�ÉyFáªÚÀG1xT€çMâk,Ø“~×Ž°3Ù¥¡Ö)ï,Œð`éèq4�†
K»)zülT›44ì—îªæ,Z¬ gˆË%Ý
à{ÍöX
HõX,¸œé´îÓŽ|zá«)VFí?‡d·v½‹ÔY`l”ÿj=Ò“8l½iËkgL5e´Õ’+Xå+owûw@EèàéöÊIr„[oS„E~hx"˜1
Ù¦Ç“Ö¾‡d¼' $þ&¸ÅD"_gµ›è«÷½cì}N]Ê/‘ý!íýwUÕèûc“ýLcYã³ç àš­:Ø\
è¹¥QÜóÕ‚A•¾@�_ØÖ©’¯y<-DYr?e§°‹ÿAÿÈŸ2I×—’h(¸bn�¹šcÏzáoHq�+0{fš©O€ùŒâB2>w* È4HýÊÍñêò~ÀÎüŠ‹4ÿ�ÏD�3žÔü�˜õTÇH‰²Ê{Z�K^.s`ä'9=¨íU ökA3.ClEo]LÖØ¹Ênëß!b~œŠ’ãëÛÏÏVoG:ü�¬úà<µXA§ ­wˆ˜ýð
lAC\T6•Ž$IPX£’Ë:ýRˆ!pÎnXcõ]ÁÄ½“kÑ*´|á«ž�V„�¼ù¨¡ä›ªåEØ4XJêúaòÕi*ëíÅû2Ág•ª“öÚš*™w=<ˆîÜ¡ ÒÙ:9/,l�/   qO°í©Qz) ÃÌ+  y­Z™±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ù<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="0" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6280-6384" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4091-4212" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2907-3042" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2015-2239" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2727-3056" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2285-2713" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4663-5248" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3123-3917" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="11" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6210" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5419-6210" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6211-6279" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="12" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1968" maxFusedRunOn="1968" detectionMode="exactProteinMatch"><Segment range="1948-1965" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="HHHHHH"/></Q></Feature><Feature recentID="13" name="ANXA2" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1968" maxFusedRunOn="1968"><Segment range="931-1947" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¨<Notes>
<UUID>8fc1cdf2-1d99-4b7b-851f-ed1c0bc3a956</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-ANXA2(human)-6Ã—His-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="20:39:51">2025.9.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                             /<StrandColors><TopStrand><ColorRange range="0..1946" colors="black"/><ColorRange range="1947..1970" colors="light blue"/><ColorRange range="1971..2654" colors="black"/><ColorRange range="2655..2656" colors="magenta"/><ColorRange range="2657..6447" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1946" colors="black"/><ColorRange range="1947..1970" colors="light blue"/><ColorRange range="1971..2654" colors="black"/><ColorRange range="2655..2656" colors="magenta"/><ColorRange range="2657..6447" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
